Markedly increased phosphorylated STAT1 (p-STAT1) on serine 727, but not tyrosine 701, was detected in podocytes from patients with DKD (Figure 5A), while in DKD mice, the abundance of p-STAT1 on serine 727 and tyrosine 701 was both largely increased and accompanied by mTORC1 signaling activation in podocytes (Figure 5B). This evidence concerns the gene STAT1 and diabetic kidney disease.