Therefore, the deletion of hepatic GR leads to fasting hypoglycemia (Opherk et al., 2004), while adrenalectomy abrogates the induction of gluconeogenesis by fasting, glucagon, cAMP, or epinephrine in rodents (Exton et al., 1972; Winternitz et al., 1957). This evidence concerns the gene NR3C1 and Hypoglycemia.