The Cancer Genome Atlas (TCGA) introduced a set of criteria that classify endometrial carcinoma into four molecular subtypes, namely polymerase ε (POLE) ultra-mutated, high microsatellite instability (MSI-high) hypermutated, copy-number low (CNV-L), and copy-number high (CNV-H), based on their mutation characteristics, copy-number alterations, and microsatellite instability. The gene discussed is POLE; the disease is endometrial carcinoma.