GRIA2 and concussion: Our analysis of brain-derived EVs was limited to those expressing GluR2+, and by expanding our approach to mTBI biomarker development—from broadening the EV subtypes and cargo that we isolate to surveil a more comprehensive set of cells affected by TBI, to advancing the technologies with which we measure and analyse this complex information—we can improve our ability to diagnose mTBI, and to extend this approach to monitor mTBI outcome and identify accurate treatment strategies.