For both mTBI and control subjects, abundance of three of the four (GFAP, NFL and UCHL1) display significant differences in plasma compared to GluR2+ EVs, and Tau abundance is significantly elevated in GluR2+ EVs in the mTBI group (P < 0.05 across all brain-derived proteins; Fig. 4B). The gene discussed is NEFL; the disease is concussion.