MTDH promotes multiple hall markers of aggressive cancer behaviors, including tumor proliferating, metastasis, angiogenesis, and chemotherapy resistance, by activating MAPK, PI3K/AKT, and WNT/β-catenin pathways in diverse cancers (Manna and Sarkar, 2021; Yoo et al., 2011). This evidence concerns the gene MTDH and neoplasm.