As has been illustrated to induce inflammation by activating ERK1/2 (extracellular signal-regulated kinase1/2), JNK (c-Jun amino-terminal kinase), and mitogen-activated protein kinase (MAPK) pathways that could induce neurodegenerative diseases and behavioral alternation [9, 58, 59]. This evidence concerns the gene MAPK8 and neurodegenerative disease.