Transcriptional regulators of HNRNPK such as brain-derived neurotrophic factor (BDNF) were upregulated in gliomas [22, 23], and we hypothesized that the AGPS-HNRNPK complex could facilitate to regulate tumor-related mRNA by BDNF, which would be explored in further study. Here, HNRNPK is linked to central nervous system cancer.