PPARA and hepatocellular carcinoma: Moreover, metabolism of cytochrome P450 (NES = −1.80 and FDR = 0.032), fatty acid metabolism (NES = −1.81 and FDR = 0.036), glycine serine and threonine metabolism (NES = −1.87 and FDR = 0.030), PPAR signaling pathway (NES = −1.65 and FDR = 0.021), and primary bile acid biosynthesis (NES = −1.92 and FDR = 0.038) were markedly activated in HCC subjects with low TLR-based RS (Figure 4B).