The TLR-based RS was determined in each HCC subject as follows: RS = MAP2K2 expression * 0.0335734255703416 + IRAK1 expression * 0.0992603217488045 + RAC1 expression * 0.186397323163475 + TRAF3 expression * 0.112022105244872 + MAP3K7 expression * 0.0570747003763387 + SPP1 expression * 0.0601842657782517. Here, SPP1 is linked to hepatocellular carcinoma.