CD4 and neoplasm: Human tumor-infiltrating lymphocytes (TILs) such as CD8+ cytotoxic T cells, conventional CD4+ T cells, T follicular helper cells (TFH) (van der Leun et al., 2020), B cells (Wouters and Nelson, 2018), and natural killer cells (Stabile et al., 2017) are generally associated with favorable (anti-tumor) immune responses, together with γδ T cells (Lo Presti et al., 2020) and eosinophils (Grisaru-Tal et al., 2020).