A recent study has also shown that another TRPC5 channel inhibitor GFB-8438, which has a IC50 of 0.18 μM, protects mouse podocytes from injury induced by protamine sulfate (PS) in vitro and significantly reduces both urinal total protein and albumin levels in a hypertensive deoxycorticosterone acetate (DOCA)-salt rat model of FSGS (43). The gene discussed is ALB; the disease is focal segmental glomerulosclerosis.