Consistently, ectopic RMRP dramatically increased the level of AKT protein as well as its phosphorylated form in JIMT-1 and BT549 cells (Figure 3E), while knockout or knockdown of RMRP resulted in the significant reduction of AKT and phosphorylated AKT in both breast cancer cell lines (Figure 3F). This evidence concerns the gene RMRP and breast carcinoma.