The bubble plot (Figure 6A) demonstrated that the riskScore was positively correlated with tumor associated fibroblasts (CAFs), monocytes, M2 macrophages, myeloid dendritic cells, endothelial cells and other immune cells, and showed a negative correlation with CD4+ T cells, Natural Killer (NK) cells, and plasma B cells (Supplementary Table 4). This evidence concerns the gene CD4 and neoplasm.