Analysis of isolated tau fractions from neuroblastoma cells (Arrasate et al., 2000) and rat cortical neurons (Pooler et al., 2012) reveals that membrane-bound tau is reactive with the tau-1 antibody, which specifically binds tau dephosphorylated in the 192–204 region [complementary to the phospho-epitope of AT8 (Szendrei et al., 1993)]. The gene discussed is MAPT; the disease is neuroblastoma.