Tau-based pathogenic hallmarks spread around the brain correlating with neurodegenerative disease progression (Braak and Braak, 1991; Kaufman et al., 2018), and β-sheet rich misfolded tau has been proposed to seed fibrillation of intrinsically disordered tau monomers in vitro and in vivo (Clavaguera et al., 2009; Peeraer et al., 2015). This evidence concerns the gene MAPT and neurodegenerative disease.