Unsurprisingly, the five tumor progression pathways [TGF-β signaling, EMT, extracellular matrix (ECM), interferon (IFN)-γ, and WNT signaling] were more activated in C2 than in C1 and C3 (Figure 2A, middle, and Supplementary Figure 2). This evidence concerns the gene TGFB1 and neoplasm.