It has even been documented that MIF induces TNF production in monocytes, activates β-catenin in osteoblasts and promotes the mineralization of osteoblasts, indicating that the MIF/CD74 axis is linked to inflammation and new bone formation seen in ankylosing spondylitis (Ranganathan et al., 2017). The gene discussed is MIF; the disease is ankylosing spondylitis.