TNF and inflammatory bowel disease: The ABIRISK cohort of 560 patients with autoimmunity (multiple sclerosis n = 147, rheumatoid arthritis n = 229, IBD n = 184) on anti-TNF and other biologic therapeutics showed a 1.5- and 4-fold risk for immunogenicity in heterozygotes and homozygotes for HLA-DQA1*05, respectively.