Our finding that TRIM22 is one of the most abundantly expressed TRIM proteins in lung tissue came as a surprise (Figures 1, 2), as the expression of TRIM22 has been widely reported to require viral infection or immune stimulation in multiple cell culture model systems [Figure 3 and Figure S1; (Hattlmann et al., 2012; Di Pietro et al., 2013)]. This evidence concerns the gene TRIM22 and viral infectious disease.