CD274 and neoplasm: found in mice bearing subcutaneous LL/2 lung tumors or B16F10 melanoma tumors that highly hypo-fractionated radiation to 23Gy in 2 fractions reduced recruitment of MDSCs into the tumor microenvironment and decreased PD-L1 expression compared with more modestly hypo-fractionated radiation to 36Gy in 9 fractions (65).