UBA1 and cancer: Interestingly, both networks highlighted the various interactions of common gene DDX3X and UBA1 gene in both GB and LGG, showing differential methylation and expression in males over females, that are reported in a variety of cancers showing the dual roles of DDX3X and oncogenic role of UBA1 (16, 17) that can be a potential substance for study in the context of expression and methylation and its interacting partners in GBM.