As downstream targets of the TGFβ1/SMAD3 pathway and essential participants in EMT promotion, N-cadherin, Vimentin, E-cadherin and Snail were found to be regulated by SMYD3 and ITGB6 and could contribute to enhanced invasion and adhesion in ovarian cancer spheroids. This evidence concerns the gene TGFB1 and ovarian carcinoma.