Surprisingly, we also found that the expression of SMYD3 and ITGB6 could be upregulated after TGFβ1 treatment, which formed a positive feedback loop among SMYD3/ITGB6/TGFβ1 to enhance the invasion and adhesion of ovarian cancer spheroids by regulating the expression of E-cadherin, N-cadherin, Snail and Vimentin (Figure 7). Here, CDH1 is linked to ovarian carcinoma.