For example, DON (sublethal dose) of less than 100 nM promoted the inflammatory effects through MAPK and NF-κB pathways, thereby increasing neuronal damage caused by infection, while DON (toxic dose) of IC50 reduced microglial sensing for LPS through cytotoxic effects, leading to the risk of decreased anti-infection efficiency [92, 111]. This evidence concerns the gene NFKB1 and infection.