By carrying the selective cytokines such as monocyte chemoattractant protein 1 (MCP-1), interferon-inducible protein 10 (IP-10), and stromal cell-derived factor 1 (SDF-1), MSC-exosomes could favor MM cell proliferation, migration, and survival and induce drug resistance to bortezomib [100], which revealed a novel agent for drug resistance in MM. This evidence concerns the gene CXCL12 and Miyoshi myopathy.