SREBF1 and gestational diabetes: Further analysis in this study showed that the protein expression of SREBP1 and its downstream proteins involving FAS, ACC, and SCD-1 in the mice were downregulated markedly after oral administration of 4 pmol/g and 12 pmol/g metabolitin, which was supported by another study, suggesting that expression increase of FAS, ACC, SCD-1, and SREBP1 was inhibited by diosgenin, so as to ameliorate gestational diabetes [34].