BDNF and irritable bowel syndrome: After intrathecal injection of BDNF antibody in the dorsal root ganglia of rats with inflammatory pain, the body aches of rats were significantly reduced and the expression level of BDNF in the spinal dorsal horn and hippocampus was also reduced [31], indicating that high BDNF expression in the peripheral nervous system may be an important cause of visceral hypersensitive pain in IBS and other inflammatory pain.