MM and EA treatments significantly reduced the AWR scores as well as the protein and mRNA expressions of BNDF and TrkB in the dorsal root ganglia and enteric nervous systems of IBS rats, suggesting that EA and moxibustion may weaken the noxious stimuli and reduce the hypersensitivity of the intestine, thereby achieving their therapeutic effects in IBS. This evidence concerns the gene NTRK2 and irritable bowel syndrome.