Being a prototypic systemic autoimmune disease, our study is aimed at addressing the frequency of AIRE single-nucleotide polymorphisms (SNPs) rs2075876 (G>A) and rs760426 (A>G) in SLE patients compared with the controls, and their relation to the phenotypic disease expression in an Egyptian cohort. The gene discussed is AIRE; the disease is systemic lupus erythematosus.