Regarding frequencies of AIRE gene (rs2075876 and rs760426) haplotypes in the study group and the association with SLE, the A allele (in rs2075876 SNP) and the G allele (in rs760426 SNP) were coexistent in 54% of SLE patients in contrast to 46% of controls with a significant difference (p value = 0.014; OR = 10.95 (1.65-72.62)). Here, AIRE is linked to systemic lupus erythematosus.