An increase in the expression levels of genes of the Wnt β-catenin cascade involved in CRC, which include c-Myc [46], Cyclin D1 [47], matrix metalloproteins (MMPs) [48], and Musashi1 (Msi1) [49], results in the activation of aberrant Wnt β-catenin signaling in colonic epithelial cells and subsequent development and progression of CRC. The gene discussed is CCND1; the disease is colorectal carcinoma.