PTGS2 and infectious otitis media: Using a mouse model in which CRC was induced via AOM and DSS, together with real-time quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC), Hao et al. have shown that CUR significantly suppresses tumor cell proliferation of colorectal tissue through the downregulation of interleukin-1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2), β-catenin, and Axin-2, which was mediated by the inactivation of the Wnt β-catenin signaling pathway [64, 67].