TP53 and colorectal carcinoma: Another study by Jaiswal et al., which was conducted to determine the underlying mechanisms related to CUR's inhibition of CRC cell growth, demonstrated that CUR, in a time-dependent manner, caused p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT116(p53(+/+)), HCT116(p53(−/−)), and HCT116(p21(−/−)) cell lines.