It is thought that that the combination of RES and tetrac to induce apoptosis of CRC cells is mediated by inhibiting Wnt β-catenin-induced overexpression of β-catenin and high mobility group protein A2 (HMGA2), as well as increasing both the nuclear accumulation of COX-2 and the expression levels of p53 [108]. The gene discussed is PTGS2; the disease is colorectal carcinoma.