TCF4 and colorectal carcinoma: In a study by Jeong et al., it was demonstrated that RES induced apoptosis of human CRC cell lines (including HCT116 and LoVo) in a dose and time-dependent manner by increasing the proteolytic proteasomal degradation of TCF4, reducing a downstream target of TCF4 (i.e., c-Myc), and decreasing exogenous Myc-tagged TCF4 without changing expression levels of β-catenin [110] (Table 3).