WNT3A and colorectal carcinoma: Based on the activity of firefly luciferase (FL), it was demonstrated that CUR and its analogs inhibit cell proliferation of several CRC cell lines (e.g., HCT116, SW480, HCT15, and DLD-1) by decreasing FL and SEAP activity induced by Wnt3a-CM, reducing the expression and degradation of cytoplasmic β-catenin, and downregulating a positive regulator of this signaling pathway called p-300 activator [74].