Two genes emerged for their functions known to play a role in neurodevelopmental disorders, namely SHISA7 and U2AF2. Indeed, in Decipher at least one NDD case with a duplication that partially overlaps the TDB and the SHISA7 gene (Patient 338729) was reported while no similar duplications, implicating brain-expressed genes, were reported among controls. Here, U2AF2 is linked to neurodevelopmental disorder.