VEGFA and neoplasm: In a hypercoagulable state, tumor cells can interact with PLT immediately (within 2min) after leaving the primary site and entering the bloodstream, and PLT aggregates and secretes VEGF, which increases the local vascular density of the tumor (Krenn-Pilko et al., 2015), immediately surrounding the tumor cells and protecting them from blood impact and NK cell-based immune responses (Placke et al., 2011).