Hao et al. (2019) have revealed that TGF-β induces EMT to promote tumorigenesis. The inhibition of TGF-β by UV disrupted immune homeostasis in systemic lupus erythematosus (SLE; Rekik et al., 2018). In addition, several situations reported the cross talks between the TGF-β and hedgehog signaling pathways (Pelullo et al., 2019). Then, we performed GSEA of the “HALLMARK_COAGULATION” gene sets and found that it was strikingly positively enriched in IDC samples (Figure 1B). Here, TGFB1 is linked to systemic lupus erythematosus.