Microtubule-actin crosslinking factor 1 (MACF1), is known to play an important role in regulating cytoskeleton dynamics, cell migration, growth and differentiation, and its abnormal expression has been closely connected to schizophrenia, Parkinson’s disease, cancer and osteoporosis (Hu et al., 2017). This evidence concerns the gene MACF1 and osteoporosis.