In the context of SARS-CoV-2 infection or COVID-19 immunization, determining IgM antibodies early in the event (within 2 weeks that may persist up to nearly 3 weeks following disease onset or immunization) and IgG antibodies (beyond 2 weeks until several months after infection or immunization), have been evidently recognized to be more informative for evaluating antibody-based immunological responses with sufficient sensitivity and specificity (31–33). The gene discussed is CD40LG; the disease is infection.