The antiphospholipid syndrome (APS) is formally defined as the association of arterial/venous thrombosis and/or recurrent miscarriages in the absence of any other known cause and the persistent presence of antiphospholipid antibodies (aPL) detectable by solid-phase (beta2 glycoprotein I [β2GPI]-dependent anticardiolipin [CL] and anti-β2GPI) or functional coagulation assays (lupus anticoagulant—LA) (Table 1) (1). Here, FASLG is linked to autoimmune polyendocrinopathy.