CALR and neoplasm: Immunogenic cell death (ICD) can be induced by radiation therapy in a dose-dependent way and is composed of the induction of organellar and cellular stress, accompanied by the release of neoantigen and endogenous danger signals-damage associated molecular patterns (DAMPs) from dying tumor cells, such as high-mobility group box 1 (HMGB1), adenosine triphosphate (ATP), as well as exposure of calreticulin (10, 11).