These kind of granulomas can cause severe tissue damage and it may be suggested that the production of 1,25(OH)2D3 is part of a negative feed-back mechanism to reduce tissue damage, as 1,25(OH)2D3 both inhibits IFN-γ and IL-17A production and induces a shift from M1 towards M2 macrophages (13–15, 43, 44). Here, IFNG is linked to Granuloma.