TNF and obesity due to melanocortin 4 receptor deficiency: TM includes a homolog of bacteria flagellin activated tlr5 (39), chemokines, cytokines and receptors, and genes involved in the metabolism of lipid mediators, extracellular proteins, such as emblematic markers of inflammation serum amyloid a and cathelicidin and less investigated c1q and tnf domain proteins, members of a large multi-gene family, which has been known mainly in association with adipocyte differentiation and obesity (40).