This includes repression of genes that are also aberrantly repressed by loss of function of two DLBCL epigenetic tumor suppressor genes TET2 and KMT2D. Tet2 normally mediates enhancer cytosine hydroxymethylation whereas Kmt2d mediates enhancer H3K4 mono and demethylation (60, 61). This evidence concerns the gene KMT2D and neoplasm.