Nonetheless, taking together the apparent impairment in DNA damage sensing that we observed in Smc3wt/– GC B-cells and more frequent mutations in AICDA off-target genes in Smc3/Bcl6 lymphomas does suggest a potential genetic contribution of Smc3 deficiency to lymphomagenesis, pointing to the need for further investigation into this possibility. The gene discussed is SMC3; the disease is lymphoma.