In order to explore whether these changes in gene expression or other aspects of the malignant phenotype might be linked to 3D architectural effects, we performed in situ Hi-C in lymphoma cells collected from involved mesenteric lymph node tumors of moribund Bcl6 (n=3) and Smc3/Bcl6 (n=3) mice. The gene discussed is SMC3; the disease is lymphoma.