SMC3 and medical procedure: To explore whether this aggressive phenotype was linked to aberrant transcriptional programming, we performed RNA-seq from mesenteric lymph node lymphoma cells from the Smc3wt/wt;Cγ1wt/cre;IμBcl6 (Bcl6) and Smc3wt/–;Cγ1wt/cre;IμBcl6 (Smc3/Bcl6) mice, verifying the expected reduced expression of Smc3 (Figure 1A, Supplementary Table 1, and Supplementary Figure 1A).