In this study, we respectively constructed specific miRNA-mRNA regulatory networks of obesity-related ccRCC for both VAT and SAT, and 3 RNA pairs (i.e. hsa-miR-182&ATP2B2, hsa-miR-532&CDH2 in VAT; and hsa-miR-425&TFAP2B in SAT) were finally screened out. This evidence concerns the gene CDH2 and obesity due to melanocortin 4 receptor deficiency.