performed a data-mining study by combining GEO with TCGA datasets, and 5 genes correlated with both ccRCC and obesity were found (IGHA1 and IGKC were oncogenes, and MAOA, MUC20 and TRPM3 were tumor suppressor genes) (19). The gene discussed is TRPM3; the disease is obesity due to melanocortin 4 receptor deficiency.