CDH2 and nicotine dependence: As shown in Table 1, target mRNAs in the miRNA-mRNA network of obesity in VAT were enriched in 6 pathways as following: nicotine addiction (hsa05033; genes: CHRNA7 and GABRA6); cholinergic synapse (hsa04725; genes: CACNA1F, CHRNA7, and SLC5A7); vascular smooth muscle contraction (hsa04270; genes: ARAF, CACNA1F, and CALCRL); mineral absorption (hsa04978; genes: ATP2B2 and MT1A); non-small cell lung cancer (hsa05223; genes: ALK and ARAF); arrhythmogenic right ventricular cardiomyopathy (hsa05412; genes: CACNA1F and CDH2).