MAP3K8 and obesity due to melanocortin 4 receptor deficiency: As results showed, 5 DE mRNAs (SORCS1, FLRT3, HIBADH, CATSPER1, and MAP3K8) and 5 DE miRNAs (hsa-miR-3130-2, hsa-miR-148b, hsa-miR-2681, hsa-miR-4487, and hsa-miR-3613) of obesity-related ccRCC with statistically significant adjusted HRs remained consistent trends (up- and down-regulated) as shown in DE analyses of obesity in VAT.