Moreover, thyroid hormones play significant roles in metabolism, and it is reported that triiodothyronine (T3) can increase the levels of adiponectin and leptin as well as improve insulin sensitivity, while irisin has least impact on adipokines levels, but it plays role in prevention of obesity or body weight regulation owing to its effects upon lipid profile (De Oliveira et al., 2020). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.