C-Myc expression was enhanced by the Wnt signaling activator (6-bromoindirubin-3ˊ -oxime (BIO), a glycogen synthase kinase (GSK)-3β inhibitor that activates c-Myc expression (Meijer et al., 2003; Rottmann et al., 2005) and by plasmid pcDNA3-cMyc in OACM5.1 C esophageal cancer cells which have the lowest c-Myc expression among the tested cell lines. Here, MYC is linked to esophageal cancer.