MYC and cancer: Using a panel of human esophageal cancer (EC) cell lines, including both esophageal adenocarcinoma (EAC) cell lines (OE19, OE33, ESO26, SK-GT-2, Flo-1, ESO51, and OACM5.1C) and esophageal squamous cell carcinoma (ESCC) cell lines (KYSE270 and OE21), we observed strong expression of c-Myc protein in most cancer lines (Figure 1A).