In this study, we have targeted the type I insulin-like growth factor receptor 1R/IR (IGF-1R) with the small molecule inhibitor BMS-754807 (Awasthi et al., 2012a) in high c-Myc expressing OE19 esophageal cancer cells, as OE19 showed very strong expression of IGF-1R (data not shown). Here, IGF1R is linked to esophageal cancer.