APP and Alzheimer disease: BACE1-AS was significantly increased in the blood samples of patients with AD, and knockdown of BACE1-AS by siRNA increased the primary hippocampal neuron proliferation in vitro. Also, BACE1-AS knockdown mediated by lentivirus improved memory and learning behaviors in SAMP8 mice, inhibited BACE1, APP production, and phosphorylation of tau protein.