RPPH1 and Alzheimer disease: Gu et al. showed that the levels of rpph1 and miR-122 are increased in AD mice, and rpph1 by binding to miR-122 leads to the activation of the Wnt/β-catenin and Aβ-induced neuronal apoptosis in SH-SY5Y cells (Qasim et al., 2020).