In Alzheimer's disease, the expression of MAGI2-AS3 increases, and miR-374b-5p expression decreases. Decreased MAGI2-AS3 expression and increased miR-374b-5p expression reduce Aβ-induced neurotoxicity and inflammation. The MAGI2-AS3/miR-374b-5p axis can be considered as a biomarker. Here, PDS5B is linked to early-onset autosomal dominant Alzheimer disease.