Approximately 100 dysregulated lncRNA were found in Aβ-treated SH-SY5Y cells, for instance, upregulation of SNHG1, RN7SL1, SCARNA9 and downregulation of SNHG16, RGS5, AGAP2-AS, LINC01963.  Therefore, these lncRNAs may play a critical role in AD pathology through altered signal pathways. Here, RGS5 is linked to Alzheimer disease.