In Aβ1-42-incubated ECs, the expressions of LINC00094 and Endophilin-1 were increased, and the expressions of miR-224-5p/miR-497-5p were decreased. Also, the Silencing of LINC00094 promotes MEM's effect on decreasing blood-brain barrier permeability in the AD microenvironment. This evidence concerns the gene SH3GL2 and Alzheimer disease.