Expression of linc00507 is elevated in the Alzheimer's disease model. The MAPT and TTBK1 genes are the direct targets of miR-181c-5p.  By binding to miR-181c-5p as a ceRNA, linc00507 inhibits miR-181c-5p and increases the expression of its target genes involved in tau phosphorylation. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.