MAPT and Alzheimer disease: Both of the AD-linked proteins, Aβ and tau, have been associated with impaired synaptic network activation, where Aβ was shown to induce hyperexcitability, while tau has shown conflicting results, both enhancing and inhibiting network activity in the cortex of mice (Crimins et al., 2011; Angulo et al., 2017; Busche et al., 2019).