Iberiotoxin has been shown to increase the duration of the beta cell action potential by delaying rectifier currents, and subsequently increase insulin secretion in human pancreatic beta cells.137,179 However, whilst iberiotoxin has helped with understanding of beta cell secretory dynamics, therapeutic promise could be compromised by lack of specificity, as BK channels also play an important role in the CNS.180 Thus, further study into the therapeutic potential and safety profile of iberiotoxin in diabetes is still required. Here, INS is linked to diabetes mellitus.