ATG8B is the part of LC3 conjugation system [22].ATG8B predominantly acts as an adapter for the autophagy machinery at the outer membrane of autophagosome, and is essential for autophagosome biogenesis/maturation and it also functions as an adaptor protein for selective Autophagy [22].Overexpression of ATG8B resulted in poor prognosis of Tamoxifen resistance breast cancer patient, having p-value =0.00056 and HR= 0.58 (0.42-0.79) (Table 1 - see PDF) (Figure 3A). The gene discussed is MAP1LC3A; the disease is breast carcinoma.