As EphB2 is highly correlated with cholesterol biosynthesis genes at mRNA level, we thus determined the correlation of cholesterol biosynthesis genes with EphB2 in a cohort of 21 human colon tumors by western blot and demonstrated that HMGCS1, HMGCR, FDPS, and SQLE positively correlated with EphB2 protein expression (Fig. 3G). This evidence concerns the gene EPHB2 and colonic neoplasm.