As EphB2 is highly correlated with cholesterol biosynthesis genes at mRNA level, we thus determined the correlation of cholesterol biosynthesis genes with EphB2 in a cohort of 21 human colon tumors by western blot and demonstrated that HMGCS1, HMGCR, FDPS, and SQLE positively correlated with EphB2 protein expression (Fig. 3G). The gene discussed is HMGCS1; the disease is colonic neoplasm.