Here, we report an association between vertigo in humans and a missense mutation in OTOG (Thr375Ser, rs7130190-T, EAF = 16.2%, P = 9.0 × 10−14, OR = 1.08) and OTOGL (Gln1102His, rs10862089-T, EAF = 7.50%, P = 1.2 × 10−13, OR = 1.11). This evidence concerns the gene OTOGL and Vertigo.