CD40LG and COVID-19: About the immune response, it has been declared that the combination of IgG and IgM achieves an overall sensitivity of 87.8% and specificity of 98.9% for detecting SARS-CoV-2; nevertheless, the complexity of the humoral response in COVID-19 is not fully elucidated, and the relevance of the SARS-CoV-2 antibody response for the long-term clinical outcome of viral clearance is still lacking.