In the present study sFlt-1 higher quartiles were associated with higher concentrations of IL-6 and the worsening of other hematochemical parameters including D-dimer, LDH, Ferritin, CRP, lymphopenia, neutrophilia, RDW-SD, especially when evaluated in severe disease compared to mild or moderate disease (survived patients) (Table2). This evidence concerns the gene CRP and lymphopenia.