MTDH and colorectal cancer: Among the top 15 candidate lncRNAs in our prediction results, 9 have been shown to be associated with colorectal Neoplasms in which MALAT1 polymorphism inhibits the binding of mir-194-5p, leading to the risk, growth and metastasis of colorectal cancer34; the long non-coding RNA HCG18 promotes the growth and invasion of colorectal cancer cells through sponging miR-1271 and upregulating MTDH/Wnt/β-catenin35; lncRNA MALAT1 promotes the colorectal cancer malignancy by increasing lncRNA DCP1A expression and miR203 downregulation36.