We found that compared to meningitis patients infected with serotype 10A, the CSF concentration of IL-6 was significantly lower in those infected with 23A and 6D, the IL-8 concentration was significantly higher in those infected with 22A, 7F and 15B/C; and the TNFα concentration was significantly higher in those infected with serotype 18A. This evidence concerns the gene CXCL8 and meningitis.