In addition, the highest Hb quartile was the only quartile with a mean s-ALT exceeding the previously reported thresholds for an increased risk for nonalcoholic steatohepatitis (> 35 U/I) and CVD-related mortality (> 40 U/I)50,51. The gene discussed is GSTM1; the disease is metabolic dysfunction-associated steatohepatitis.