Unc93b13d/3dPld3−/−Pld4−/− mice had a substantially normalized phenotype compared to Pld3−/−Pld4−/− or Tlr9CpG11/CpG11Pld3−/−Pld4−/− mice, as they survived for >8 months (Fig. 1a, lower panel) and lacked splenomegaly, anemia and thrombocytopenia (Fig. 1b–e). This evidence concerns the gene PLD3 and Splenomegaly.