Comparison of Tlr9−/−Pld3−/−Pld4thss/thss mice to Tlr9+/–Pld3−/−Pld4thss/thss littermates and to Unc93b13d/3dPld3−/−Pld4−/− mice revealed that complete TLR9 deficiency significantly ameliorated some abnormalities caused by PLD3/4 deficiency, such as thrombocytopenia. The gene discussed is PLD3; the disease is Thrombocytopenia.